About
Song Xue
Ph.D. Candidate · Fudan University
About Me
I am a Ph.D. candidate in Pathogen Biology at Fudan University (2022–present), focused on novel strategies and technologies for the prevention and treatment of emerging infectious diseases. I received my B.Sc. in Forensic Medicine from Fudan University (2017–2022).
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Core Research — Antibody-dependent enhancement (ADE) of SARS-CoV-2 variants, HBV genome heterogeneity in chronic hepatitis B, and high-throughput screening of broadly neutralizing antibodies.
Research Focus
Antibody-dependent enhancement differences across SARS-CoV-2 variants, integrating multi-omics data
High-resolution profiling of HBV quasispecies and their role in immune escape
Isolation, characterization, and functional profiling of fully human monoclonal antibodies
What This Blog Covers
This blog documents my work at the intersection of pathogen biology, immunology, and computational analysis. Four main themes:
LLM-powered research automation
Wet-lab protocols & methodology reviews
FlowJo, ChimeraX, PyMOL, Schrödinger
Practical techniques for biological data
Technical Skills
| Domain | Details |
|---|---|
| Experimental | PCR/qPCR, ELISA, Western blot, neutralization assays, ADE detection, flow cytometry, PBMC isolation, single B cell sorting, animal experiments |
| Bioinformatics | Bulk RNA-seq, scRNA-seq, targeted sequencing, cell clustering, differential expression, pathway analysis, viral genome alignment |
| Programming | R (tidyverse, ggplot2), Python (pandas, numpy, scipy, matplotlib) |
| Visualization | FlowJo, ChimeraX, PyMOL, ggplot2, scientific figure preparation |
Publications
- Xue, S., Han, Y., Wu, F., Wang, Q. Mutations in the SARS-CoV-2 spike receptor binding domain and their delicate balance between ACE2 affinity and antibody evasion. Protein & Cell, 2024.
- Wu, J., Chen, Z., Gao, Y., Wang, Z., Wang, J., et al. Fortuitous somatic mutations during antibody evolution endow broad neutralization against SARS-CoV-2 Omicron variants. Cell Reports, 2023.
- Xia, A., Wang, X., He, J., Wu, W., Jiang, W., Xue, S., et al. Cross-reactive antibody response to Monkeypox virus surface proteins. BMC Biology, 2023.
- Jiang, W., Wu, J., He, J., Xia, A., Wu, W., Gao, Y., Zhang, Q., et al. Re-evaluation and retrospective comparison of serum neutralization induced by three different types of inactivated SARS-CoV-2 vaccines. Vaccines, 2024.